美味牛肝菌多糖的生物活性及其抗S-180肿瘤的效应
Study of the Biological Activity and the Antitumor Activity Against Sarcoma-180 of Boletus Edulis
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摘要: 美味牛肝菌(Boletus edulis)子实体，经水溶醇析法提取的多糖呈灰白色，其总糖含量为73.21%，蛋白质含量为7.14%.经动物试验表明：该多糖(BP)能显著增加胸腺、脾脏器官质量，并可促进机体的免疫功能.采用ip,100 μg/(kg．d)剂量后，可使供试小白鼠外周血中的白细胞总数增加17%，同时红细胞中SOD酶活性显著提高，多达42.5%.还可显著促进脾淋巴细胞的转化.采用多糖液0.1 mL/(只．d)，剂量为10 mg/(kg．d)，腹腔注射已感染S-180肿瘤的小鼠，同样还能提高其生命延长率18.78%，具有明显的抗S-180肿瘤的效应.Abstract: A grey polysaccharides,with the content of 73.2 percent of total sugar and 7.14 percent of protein,was extracted from the hot water of fruiting body of Boletus edulis by addition of ethanol.The study of animal experiment indicated that the polysaccharides of Boletus Edulis could increase the weight of thymuses and spleen obviously,and promoted the immune function.Treated with the dose of 100 μg/(kg．d) ip,the BP eahanced leucocyte number of peripheral of white mice by 17 percent,and improved the activity of SOD of reythrocytes noticeable by 42.5 percent？ and could also take a significant check on spleen lymphocyte transformation.Besides,treated with polysaccharides 0.1 mL/(mice．d),the dose of 10 mg/(kg．d) ip,the dose could also imprve life elongation rate of the small mice suffering from Sarcoma-180 by 18.78 percent.Thus,BP had the significant effeca on Sarcoma-180.
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Key words:
- boletus edulis polysaccharide /
- sarcoma-180 /
- biological activity .
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