考虑抗体免疫反应及免疫损害的慢性病毒感染模型及其动力学性态
Dynamics of a Chronic Viral Infection Model with Humoral Immunity and Immune Impairment
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摘要: 建立并研究了一个考虑抗体免疫及免疫损害的慢性病毒感染模型. 当病毒基本再生数大于某个阈值时, 系统呈现双稳性态. 理论分析及数值模拟表明, 通过某段有限时间的治疗可以实现长期免疫控制, 从而避免疾病进一步发展.
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关键词:
- 抗体免疫,免疫损害,免疫控制,双稳
Abstract: A chronic viral infection model with humoral immunity and immune impairment is proposed and studied. The system can exhibit a bistable behavior if the basic reproductive number of the virus is above a certain threshold. By theoretical analysis and numerical simulations, it is shown that a phase (or some phases) of therapy could shift the patient from a disease progression to a long-term immune control. -
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