Study on the Anti-Fatigue and Anti-Oxidant Effects of Natural Astaxanthin

Key words: 
• natural astaxanthin，anti-fatigue，anti-oxidation，animal experiment /
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Abstract: Objective:To verify the anti‐fatigue and anti‐oxidant activity of natural astaxanthin .Methods :Extracting natural astaxanthin from shrimp with ethanol .Choosing KM mice as the experimental animals and dosing continuously lasting up to 30 days and recording their weight changes .Measuring exhaustion swimming time and activity of the anti‐oxidant enzyme system (T‐SOD ,GSH‐Px ,T‐AOC ,MDA and NO) of the liver tissue of the mice through loaned‐swimming test .Determining the changes of BLA , BUN ,LG and MG in the blood and measuring blood sugar levels and the activity of the antioxidant enzyme system after 20 min swimming .According to the linear equation ,analyzing the relationship between anti‐fatigue and anti‐oxidant activities of natural astaxanthin .Results :Natural astaxanthin could increase the swimming time of mice ,reduce BLA and BUN levels after swimming ,improve LG and MG ,and blood sugar levels ,and raise the contents of T‐SOD ,GSH‐Px and T‐AOC and other activity indicators in the liv‐er and the blood ,and reduce the contents of MDA and NO .Correlation analysis showed that the contents of BLA and BUN were reduced and the contents of LG and MG increased with increasing T‐AOC activity . Conclusion :Natural astaxanthin has significant anti‐oxidant and anti‐fatigue effect ,and anti‐oxidant capac‐ity is positively associated with anti‐fatigue capacity .