引用本文:徐志谦[1] 、马宜雪[2] 、董伦[1] 、罗娟[1] 、蒲道俊[1].非洛地平固体分散体缓释片的研制与优化[J].西南师范大学学报(自然科学版),2017,42(8):
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非洛地平固体分散体缓释片的研制与优化
徐志谦[1] 、马宜雪[2] 、董伦[1] 、罗娟[1] 、蒲道俊[1]
作者单位
徐志谦[1] 、马宜雪[2] 、董伦[1] 、罗娟[1] 、蒲道俊[1] 西南药业股份有限公司,重庆,400038 西南大学 药学院,重庆,400715 
摘要:
为探讨非洛地平固体分散体缓释片的研制与优化,在单因素试验的基础上,采用正交试验设计的方法,对处方因素进行详细的考察,进一步优化处方工艺,并对按最优处方制备的样品进行验证.结果显示:优选的非洛地平固体分散体缓释片处方工艺合理,由其制备的缓释片体外释药2h释放度为20%~25%,4h释放度为44%~46%,8h释放度为78%~84%,12h释放度为96%~100%.
关键词:  非洛地平  固体分散体  缓释片  亲水凝胶  羟丙甲基纤维素
DOI:10.13718/j.cnki.xsxb.2017.08.017
分类号:R944.4
基金项目:
On Optimization and Preparation of Felodipine Solid Dispersions and its Sustained-Release Tablets
XU Zhi-qian[1],MA Yi-xue[2],DONG Lun[1],LUO Juan[1],PU Dao-jun[1]
Abstract:
To improve the release of Felodipine, solid dispersion techniques were used, and a 12h sustained-release drug was prepared with the solid dispersions.Solid dispersions (SD) were prepared by melting method with PEG6000 as a carrier.On the basis of the single factor test, the orthogonal test was conduct to get optimized formulation, which took two kinds of HPMC as sustained-release material, and sustained-release tablet was prepared by powder direct-compression method.Results show that the release of Felodipine was improved markedly with the solid dispersion techniques.Also, the drug release of self-made sustained-release tablet and the reference drug were consistent highly in vitro.the whole key quality of sustained-release tablet meet the requirements.It is concluded that the way that sustained-release drug were prepared with solid dispersions, which were made first to improve the dissolution of drug is a simple and feasible thought.
Key words:  Felodipine  solid dispersions  sustained release tablet  hydrogel  HPMC
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