Abstract: This study was designed to explore the effect of the Jin Weng Zhi Li granule on immune regula‐tion of immunosuppressed mice .72 mice were divided randomly into blank group which was given physio‐logical saline ,the high dose ,middle dose ,low dose group of Jin Weng Zhi Li granule ,model group and positive medicine group were used to establishe the immunosuppressed mice models by abdominal injection of cyclophosphamide .After successful modeling ,model group was given physiological saline ,positive medi‐cine group was given 2 g/kg Astragalus polysaccharides .20 g/kg ,16 g/kg ,12.8 g/kg of the Jin Weng Zhi Li granule extract were given to the high dose ,middle dose ,low dose group of Jin Weng Zhi Li granule with once a day for 7 days by gavage .The carbon clearance index ,immune organ index ,T and B lymphocyte prolifera‐tion in immunosuppressed mice were measured .The results showed that Jin Weng Zhi Li granule could in‐crease the carbon clearance index ,immune organ index and T ,B lymphocyte proliferation in immunosup‐pressed mice ,compared with model group ,the difference was extremely significant(p<0.01) .It suggested that Jin Weng Zhi Li granule could enhance immune function of immunosuppressed mice .